个人信息:
姓名: 林俊生
职称: 教授
电话: 18659913008
邮箱: junshenglin@hqu.edu.cn / junshenglin3@hotmail.com
高等教育:
1994-1997 博士（PhD in Biomedicine）
新西兰奥克兰大学
1990-1991 工商管理毕业
澳大利亚Regent 商学院
1978-1983 医学士
福建医科大学
工作经历:
2012-至今 教授、博导
华侨大学生物医学院、医学院、临床医学院
2012-至今 兼职教授、博导
新西兰维多利亚大学生物学院
2001-2012 科学家、续聘为资深科学家
新西兰皇家科学院
1997-2000 博士后、续聘为Acadamic 研究员
新西兰奥克兰大学医学院
1991-1993 外科医师（新南威尔士州注册）
澳大利亚皇家Alfred 王子医院
1983-1989 住院医师、续聘为主治医师
福建医科大学附属第一医院外科
当前研究方向：
基于适体的诊断试剂和药物开发
蛋白质工程
近年发表的部分论著:
- Yepeng Du, Dan Liu, Min Wang, Fangke Guo, Jun Sheng Lin*, Preparation of DNA aptamer and development of lateral flow aptasensor combining recombinase polymerase amplification for detection of erythromycin. Biosensors and Bioelectronics, 2021, Volume 181, 113157. https://doi.org/10.1016/j.bios.2021.113157
- Lingli Jiang, Min Wang, Yi Zhang, Haihua Chen, Yi Su, Yiyi Wang, Jun Sheng Lin*, Preparation and characterization of DNA aptamers against roxithromycin. Anal Chim Acta. 2021 Jun 15;1164:338509. doi: 10.1016/j.aca.2021.338509.
- Wei Zhang, Danyang Li, Jianguang Zhang, Lingli Jiang, Zhaofa Li, Jun Sheng Lin*, Preparation and Characterization of Aptamers Against O,p'-DDT. Int J Mol Sci. 2020 Mar 23;21(6):2211. doi: 10.3390/ijms21062211.
- Yuquan You, Wei Zhang, Meimei Cai, Qingxin Guo, Jiawen Wang, Yaping Cai, Junsheng Lin*, Discovery of fecal microbial signatures in patients with ankylosing spondylitis, Arch Rheumatol 2023;38(x):i-xiii, doi: 10.46497/ArchRheumatol.2023.9124.
- Yuquan You, Meimei Cai, Wei Zhang*, Jun Sheng Lin*, Altered bacterial profiles at genus level in the gut of ankylosing spondylitis patients with different ASDAS scores. Int J Rheum Dis, 2022; 25(2):239-241. doi: 10.1111/1756-185X.14280.
- Liu Q, Zhang W, Chen S, Zhuang Z Zhang Y Jiang , Lin J.S*, SELEX tool: a novel and convenient gel-based diffusion method for monitoring of aptamer-target binding. J Biol Eng. 2020 Jan 13;14:1. doi: 10.1186/s13036-019-0223-y.
- Guo Z.H., Zeng Y.M., Lin J.S.*. Dynamic Spatiotemporal Expression Patterns of Limbal Stem Cell Biomarkers During Mouse Development. Exp Eye Res. 2020, 192, 107915. https://doi.org/10.1016/j.exer.2020.107915
- Guo, Z.H.; Zhang, W.; Jia, Y.Y.S.; Liu, Q.X.; Li, Z.F.; Lin, J.S*. An Insight into the Difficulties in the Discovery of Specific Biomarkers of Limbal Stem Cells. Int. J. Mol. Sci. 2018, 19(7), 1982; doi:10.3390/ijms19071982.
- Zhang W, Liu QX, Guo Z and Lin JS*, Practical Application of Aptamer-Based Biosensors in Detection of Low Molecular Weight Pollutants in Water Sources, Molecules 2018, 23(2), 344; doi:10.3390/molecules23020344
- Zhang W, Liu QX, and Lin JS*, Prevention from the Pollution of Carcinogenic Endocrine Disrupting Chemicals in Water Sources, Cancer Prevention: Current Research Journal 2017 July, 1(1):111.
- Huang X , Wang X, Xie X, Zeng S, Li Z, Xu X , Yang H, Qiu F, Lin J *, Diao Y*, Kallistatin protects against bleomycin-induced idiopathic pulmonary fibrosis by inhibiting angiogenesis and inflammation, 2017;9(3):999-1011
- Chen Y, Lin J*, The application of aptamer in apoptosis, Biochimie 2017 Jan, 132:1-8, doi: 10.1016 /j.biochi.2016.10.008.
- Wang G, Wang X , Huang X, Yang H, Pang S, Xie X, Zeng S, Lin J* and Diao Y*, Inhibition of integrin β3, a binding partner of kallistatin, leads to reduced viability, invasion and proliferation in NCI-H446 cells, Cancer Cell Int (2016) 16:90
- Lin JS*, Kauff A, Diao Y, Yang HY, Lawrence S and Juengel J, Creation of DNA aptamers against recombinant BMP15, REPROD FERT DEVELOP 2016, 28(8) 1164-1171. doi: 10.1071/RD14409
- Sun A, Lin J, Chao P, et al. Biological Evaluation of Ferrocenyl Olefins: Cancer Cell Growth Inhibition, ROS Production, and Apoptosis Activity[J]. Febs Letters, 2016, 100(1):81-4.
- Huang X, Wang X, Lv Y, Xu L, Lin JS*, Diao Y*, Protection Effect of Kallistatin on Carbon Tetrachloride-Induced Liver Fibrosis in Rats via Antioxidative Stress. PLoS ONE 2014, 9 (2), e88498
- Pang SQ, Wang GQ, Jin XQ, Sun AJ, Lin JS, Diao Y, Chemical Composition of the Fatty Oil from Fructus Broussonetiae and Its Effects on Rat Plasma Lipids and Adipose Tissue, American Journal of Plant Sciences, 2016, 7, 446-452
- Sun A, Xu X, Lin J, Cui X and Xu R, Neuroprotection by Saponins, Phytotherapy Research 2015 Feb;29(2):187-200
- Wang F, Lin J, Xu R, The Molecular Mechanisms of TRAIL Resistance in Cancer Cells: Help in Designing New Drugs, Curr Pharm Des. 2014;20(42):6714-22.
- Huang KF, Huang XP, Xiao GQ, Yang HY, Lin JS*, Diao Y, Kallistatin, a novel anti-angiogenesis agent, inhibits angiogenesis via inhibition of the NF-κB signaling pathway, Biomed Pharmacother. 2014 May;68(4):455-61
- Huang KF, Yang HY, Xing YM, Lin JS *, Diao Y*, Recombinant human kallistatin inhibits angiogenesis by blocking VEGF signaling pathway, J Cell Biochem. 2014 Mar;115(3):575-84
- Pang SQ, Wang GQ, Lin JS, Diao Y, Xua RA, Cytotoxic activity of the alkaloids from Broussonetia papyrifera fruits, Pharmaceutical Biology 2014 Oct, 52(10):1315-9
- Guo, Zhi Hou and Lin, Jun Sheng *, Targeted Therapy Against BCSCs, SM Group, 2016.11.05 http://www.smgebooks.com/breast-cancer-therapy/index.php
国际学术杂志编委
1、Editorial Board Member of SM Journal of Nephrology & Therapeutics
2、Editorial Board Member of Cancer Prevention
近年指导学生科研的奖项
PTIM国际会议最佳Post奖（核酸生物传感器的研发）
第三届全国“梦之路杯”创意组二等奖（功能性 核酸片段的检测）
代血清科研项目
核酸适配体核心产业链金牌服务平台
科研转化
