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马俊杰讲师

发布时间:2017-11-29 浏览次数:

 

马俊杰讲师

硕士生导师

电话:0595-22690323

邮箱:majunjie3612@hqu.edu.cn

学习与工作经历:

2015/07-至今,华侨大学,生物医学学院,讲师

2012/092015/06,沈阳药科大学,药物化学专业

2009/092012/06,沈阳药科大学,药物化学专业

2005/092009/07,沈阳药科大学,制药工程专业

主要研究方向:

1.基于靶点的药物的设计与评价

2.药物合成工艺的开发

3.天然产物的结构修饰

主持与参与的科研项目:

1、华侨大学中青年教师科技创新资助计划,ZQN-PY519PD-1/PD-L1免疫检查点小分子抑制剂的设计与评价,2017-202140万,在研,主持。

2、国家自然科学青年基金,81602970,新型小分子procaspase3变构激活剂的分子构建和抗肿瘤活性评价,2017-201917.30万元,在研,主持。

3、福建省自然科学基金面上项目,2017J01143procaspase-3激动剂的设计、合成以及抗肿瘤活性研究,2017-20196万,在研,主持。

4、华侨大学科研启动基金,Z15Y0075基于2羟基苯甲醛缩氨基脲结构的分子构建和抗肿瘤活性评价,2015-20184万元,在研,主持。

5、国家自然科学面上项目,21772047,靶向抑制RhoA蛋白的二萜化合物curcusoneA的抗肿瘤构效关系、结构优化和分子机制研究,2018-2022,在研,参与。

6、国家科技重大专项,2012ZX09103-101-040,新型抗乙肝病毒候选药物AG-376的研发,2012-2015150万元,已结题、参与。

发表论文:

(1) Junjie Ma, Guanglong Bao, Limei Wang, Wanting Li, Boxuan Xu, XinZhai, Ping Gong*, Design, synthesis, biological evaluation and preliminary mechanism study of novel benzothiazole derivatives bearing indole-based moiety as potent antitumor agents, European Journal of Medicinal Chemistry, 2015, 96:173-186.

(2) MA Junjie, HU Gang, XIE Lijun, CHEN Lei, XU Boxuan, GONG Ping*, Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives Bearing Semicarbazone Moiety as Antitumor Agents, Chemical Research in Chinese Universities, 2015, 31(6):958-963.

(3) Junjie Ma, Dong Chen, Kuan Lu, Lihui Wang, Xiaoqi Han, Yanfang Zhao, Ping Gong*, Design, synthesis, and structureeactivity relationships of novel benzothiazole derivatives bearing the ortho-hydroxy N-carbamoylhydrazone moiety as potent antitumor agents, European Journal of Medicinal Chemistry, 2014, 86:257-269.

(4) Junjie Ma, Guangyan Zhang, Xiaoqi Han, Guanglong Bao, Lihui Wang, Xin Zhai,and Ping Gong*, Synthesis and Biological Evaluation of Benzothiazole Derivatives Bearing the ortho-Hydroxy-N-acylhydrazone Moiety as Potent Antitumor Agents, Arch. Pharm. Chem. Life Sci, 2014, 347(12):936-949.

(5) SONG Kaizhen, MA Junjie, WANG Xiao, GONG Ping*, ZHAO Yanfang*, Synthesis and Antitumor Activities of Novel 4-Morpholinothieno[3,2-d] pyrimidine Derivatives, Chemical Research in Chinese Universities, 2014, 30(1):75-81.

(6) Mingze Qin, Xin Zhai, Hongbo Xie, Junjie Ma, Kuan Lu, Yu Wang, Lihui Wang, Yucheng Gu and Ping Gong*, Design and synthesis of novel 2-(4-(2-(dimethylamino)ethyl)-4H-1,2,4-triazole-3-yl)pyridines as potential antitumor agents, European Journal of Medicinal Chemistry, 2014, 81:47-58.

授权发明专利:

1.宫平,翟鑫,赵燕芳,刘亚婧,马俊杰。缩氨基脲衍生物及其用途,中国,ZL201410416069.2