基本信息：
马俊杰，博士，华侨大学医学院，副教授，硕士生导师
泉州市高层次人才
电话：0595-22690323/18659024618
邮箱：majunjie3612@hqu.edu.cn
学习与工作经历：
2020/01-至今，华侨大学，医学院，副教授
2015/07－2019/12，华侨大学，医学院，讲师
2012/09－2015/06，沈阳药科大学，药物化学，博士
主要研究方向：
1、基于靶点结构的药物设计与评价
2、计算机辅助药物设计
主讲课程：
现代仪器分析（色谱部分）；药物化学；药物设计与合成
科研项目：
1、福建省自然科学基金面上项目，2021J01309，2021/11-2024/11，主持。
2、泉州市科技计划项目，2018C074R，2018/08-2021-08，主持。
3、华侨大学中青年教师科技创新资助计划，ZQN-PY519，2017/10-2021/10，主持。
4、福建省自然科学基金面上项目，2017J01143，2017/04-2020/04，主持。
5、国家自然科学青年基金，81602970，2017/01-2019/12，主持。
发表论文：
(18) Yu. Wang, Huang. Kun, Yali. Gao, Dandan. Yuan, Lin. Ling, Jieqing. Liu, Sihai. Wu, Roufen. Chen, He. Li, Yizu. Xiong, Han. Liu, Junjie. Ma*, Discovery of quinazoline derivatives as novel small-molecule inhibitors targeting the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) interaction, European Journal of Medicinal Chemistry, 2022, 229, 113998.
(17) Roufen Chen, Dandan Yuan, JunJie Ma*, Advances of biphenyl small-molecule inhibitors targeting PD-1/PD-L1 interaction in cancer immunotherapy, Future Med. Chem., 2022, 14(2), 97-113.
(16) Shao, Jiang-Yang; Wu, Si-Hai; Ma, Junjie; Gong, Zhong-Liang; Sun, Tian-Ge; Jin, Yulong; Yang, Rong; Sun, Bin; Zhong, Yu-Wu. Ratiometric detection of amyloid-beta aggregation by a dual-emissive tris-heteroleptic ruthenium complex, Chem. Commun., 2020, 56, 2087-2090.
(15) 朱玉垚,王瑜,马俊杰*.组蛋白去乙酰化酶抑制剂中锌离子结合基团的研究进展[J].中国新药杂志,2020,29(10):1122-1130.
(14) Junjie Ma*, Xin Ni, Yali Gao, Kun Huang, Jiaan liu, Yu Wang, Roufen Chen, Cuifang Wang*. Identification and biological evaluation of novel benzothiazole derivatives bearing a pyridine-semicarbazone moiety as apoptosis inducers via activation of procaspase-3 to caspase-3, MedChemComm, 2019, 10(3), 465-477.
(13) Junjie Ma*, Xin Ni, Yali Gao, Kun Huang, Yu Wang, Jiaan Liu, Guowei Gong*. Semicarbazone derivatives bearing phenyl moiety: synthesis, anticancer activity, cell cycle, apoptosis-inducing and metabolic stability study, Chemical & Pharmaceutical Bulletin, 2019, 67(4), 351-360.
(12) Junjie Ma*, Kun Huang, Xin Ni, Roufen Chen, Boxuan Xu & Cuifang Wang*. Design, Synthesis, Biological Activity and Molecular Docking Study of Coumarin Derivatives Bearing 2-Methyl-Biphenyl Moiety, Chem. Res. Chinese Universities, 2019, 35, 410-417.
(11) 马俊杰*, 倪欣, 黄坤, 王瑜, 含苯并噻唑/苯基片段的香豆素衍生物的设计、合成及抗肿瘤活性研究, Acta Pharmaceutica Sinica(药学学报), 2019, 54(3), 514 −521.
(10) 倪欣, 黄坤, 马俊杰*. Procaspase-3 小分子激活剂的研究进展, 中国现代应用药学, 2019, 36(3), 368-371.
(9) 朱玉垚, 黄坤, 王瑜, 马俊杰*. HDAC多靶点抑制剂在癌症治疗中的研究进展, 聊城大学学报(自然科学版), 2019, 32(05), 71-79.
(8) Jie-Qing Liu* Ying Xu, Qin Xiao, Jin-Di Huang, Jun-Jie Ma, Chen-Lei Lian, Mei-Ying Huang, Zhen-bo Du and Cui-Fang Wang*, Dimericursones A and B: two unprecedented hexacyclic dimeric diterpenoids from the root barks of Jatropha curcas, Org. Biomol. Chem., 2018,16, 8305-8310.
(7) Ming-Ze Qin, Lei Wang, Shuang Yan, Jun-Jie Ma, YeTian, Yan-Fang Zhao, Ping Gong. Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells, Chinese Chemical Letters, 2017, 28(5), 991-994.
(6) Junjie Ma, Guanglong Bao, Limei Wang, Wanting Li, Boxuan Xu, XinZhai, Ping Gong*. Design, synthesis, biological evaluation and preliminary mechanism study of novel benzothiazole derivatives bearing indole-based moiety as potent antitumor agents, European Journal of Medicinal Chemistry, 2015, 96, 173-186.
(5) MA Junjie, HU Gang, XIE Lijun, CHEN Lei, XU Boxuan, GONG Ping*. Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives Bearing Semicarbazone Moiety as Antitumor Agents, Chemical Research in Chinese Universities, 2015, 31(6), 958-963.
(4) Junjie Ma, Dong Chen, Kuan Lu, Lihui Wang, Xiaoqi Han, Yanfang Zhao, Ping Gong*. Design, synthesis, and structureeactivity relationships of novel benzothiazole derivatives bearing the ortho-hydroxy N-carbamoylhydrazone moiety as potent antitumor agents, European Journal of Medicinal Chemistry, 2014, 86, 257-269.
(3) Junjie Ma, Guangyan Zhang, Xiaoqi Han, Guanglong Bao, Lihui Wang, Xin Zhai,and Ping Gong*. Synthesis and Biological Evaluation of Benzothiazole Derivatives Bearing the ortho-Hydroxy-N-acylhydrazone Moiety as Potent Antitumor Agents, Arch. Pharm. Chem. Life Sci, 2014, 347(12), 936-949.
(2) SONG Kaizhen, MA Junjie, WANG Xiao, GONG Ping*, ZHAO Yanfang*. Synthesis and Antitumor Activities of Novel 4-Morpholinothieno[3,2-d] pyrimidine Derivatives, Chemical Research in Chinese Universities, 2014, 30(1), 75-81.
(1) Mingze Qin, Xin Zhai, Hongbo Xie, Junjie Ma, Kuan Lu, Yu Wang, Lihui Wang, Yucheng Gu and Ping Gong*. Design and synthesis of novel 2-(4-(2-(dimethylamino)ethyl)-4H-1,2,4-triazole-3-yl)pyridines as potential antitumor agents, European Journal of Medicinal Chemistry, 2014, 81, 47-58.
专利：
1、马俊杰，王瑜，陈柔棻，刘接卿，吴四海，一种苯并芳杂环化合物及其用途，CN 112979562.
2、马俊杰, 倪欣. 一种吲哚类衍生物及其应用, ZL 201911217790.8.
3. 马俊杰, 黄坤, 倪欣, 陈柔棻, 余楚丹, 闫琦慧, 陈思颖, 侯晓林. 一种用作caspase-3激活剂的缩氨基脲类衍生物及其应用, CN 109265453.
4. 马俊杰, 黄坤, 倪欣, 陈柔棻, 余楚丹, 闫琦慧, 陈思颖, 侯晓林. 一种香豆素类衍生物及其应用, ZL 201811131802.0.
5. 马俊杰, 倪欣, 黄坤, 王翠芳. 一种用作caspase-3激活剂的香豆素类衍生物及其应用, ZL 201810631499.4.
