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刘接卿副教授

发布时间:2018-03-21 浏览次数:

 

 

刘接卿副教授

 

理学博士,硕士研究生导师

华侨大学生物医学学院药学系主任

电话:0595-22690323

邮箱:liujieqing@ hqu.edu.cn

通讯地址:福建省泉州市丰泽区城华北路269号,362021

 


简历:

教育经历

2006/09-2009/07,首都师范大学,遗传学博士;

2003/09-2006/07,吉林大学,药物化学硕士;

1999/09-2003/07,吉林大学,药学学士。

工作经历

2015/01-至今,华侨大学生物医学学院,副教授;

2013/01-2014/12,中国科学院昆明植物研究所,副研究员;

2012/01-2012/12,中国科学院昆明植物研究所,助理研究员;

2009/08-2011/12,中国科学院昆明植物研究所,博士后,合作导师邱明华研究员。


主要研究方向:

1. 天然资源尤其是中草药中新颖活性成分的提取分离和结构鉴定。

2. 从天然产物中寻找药物先导和候选结构。

3. 具有重要生物活性天然产物的结构修饰和作用机制研究。

4. 天然产物活性分子的分子探针合成及作用靶标研究。

5. 海洋微生物与天然药物研发。


科研成果:

        在科研方面一直致力于中草药活性物质基础和相关活性作用机理研究,到目前为止已分离鉴定和活性筛选了1000余个化合物,取得了多项天然药物研究成果:从小桐子中筛选出了具有抗肿瘤活性的候选化合物;从闽产灵芝中发现抗过敏活性的芳香杂萜类分子;从“维生素C之王”针叶樱桃中发现具有抑制AChE活性的新颖结构等。基本阐明抑制前列腺癌增殖和转移的候选药物CurA的分子作用机制和靶标确证工作,正进行临床前药学其他方面的研究工作;已发现对乳腺癌具有良好抑制作用的天然先导化合物分子JQ222,正进行构效关系和作用机制研究。已在天然产物化学和食品化学领域如Organic Letters, Phytochemistry, PlantaMedica, Tetrahedron, Journal of Agricultural and Food Chemistry, Food Chemistry等国际、国内杂志上发表论文50余篇。


承担参与科研项目情况:

1. 在研课题:

1) 泉州市科技局项目,灵芝三萜抗阿尔茨海默症(AD)的活性评价及其作用机制研究,主持,20万,2018.10-2021.092018C072R);

2) 国家自然科学基金面上项目,靶向抑制RhoA蛋白的二萜化合物curcusone A的抗肿瘤构效关系、结构优化和分子机制研究,主持,62万,2018.01-2021.1221772047);

3) 福建省自然科学基金面上项目,靶向抑制RhoA蛋白的二萜化合物curcusone A的抗肿瘤构效关系和结构优化,主持,4万,2018.04-2021.042018J01126);

4) 横向课题,淫羊藿次苷Ⅱ提取小试工艺开发及化学合成工艺开发,主持,66万,2017.6-2019.6Z1743087);

5) 福建省高校青年自然基金重点项目,龙血树叶辅助降血糖保健品的前期基础研究,主持,5万,2016.12-2019.12Z1625138);

6) 泉州市高端海洋人才资助项目,多色鲜花紫菜饮料和降血压功能紫菜饮料的研究开发,主持,10万,2016.6-2019.6(Z1624013)

7) 中央高校基本科研业务费,傣药摆埋嘎筛抗糖尿病活性成分及作用机制研究,主持,40万,2015.11-2019.11Z15J0025

8) 华侨大学科研启动基金,假酸浆生物活性物质基础研究,主持,7万,2015.03-2018.03(Z15Y0015)

2. 完结课题:

1)国家自然科学基金委,运用结构修饰和构建含氮二萜类似物库的方法挖掘麻疯树植物中抗肿瘤活性成分,主持,23万,2013.01-2015.12

2)国家自然科学基金委,中药灵芝中化学成分的再认识和保肝抗肝癌生物活性评价,参与,62万,2012.01-2015.12

3)院地合作,蓝莓花青素高效提取技术与中试应用,参与,50万,2012.01-2015.12

4国际合作,合作研究分析安利功能植物化学成分,参与,100万,2012.01-2015.12


获奖及荣誉:
201401月入选第十六批云南省中青年学术和技术带头人后备人才;

201411月入选龙岩市首批创新人才;

201710月入选泉州市层次人才。


代表论著:

1. Jie-Qing Liu*, Ying Xu, Qin Xiao,  Jin-Di Huang,  Jun-Jie Ma,  Chen-Lei Lian,  Mei-Ying Huang,  Zhen-bo Du  and  Cui-Fang Wang*. Dimericursones A and B: two unprecedented hexacyclic dimeric diterpenoids from the root barks of Jatropha curcas. Organic Biomolecular Chemistry. 2018, 16(37): 6927-6932.

2. Liu JQ*, Lian CL, Hu TY, Wang CF, Xu Y, Xiao L, Liu ZQ, Qiu SQ, Cheng BH. Two new farnesyl phenolic compounds with anti-inflammatory activities from Ganoderma duriporaFood Chem. 2018,263:155-162.

3. Xiao, Q.; Wang, C.-F.; Chen, J.; Lian, C.-L.; Xu, Y.; Xiao, L.; Liu, J.-Q.*, Three new withanolides from the calyces of Nicandra physaloides. Steroids 2018, 131, 32-36.

4. Yu, M.-Y.1; Zhao, G.-T.1; Liu, J.-Q.1; Khan, A.; Peng, X.-R.; Zhou, L.; Dong, J.-R.; Li, H.-Z.; Qiu, M.-H., Withanolides from aerial parts of Nicandra physalodes. Phytochemistry 2017, 137, 148-155.

5. Lian, C.-L.; Wang, C.-F.; Xiao, Q.; Xiao, L.; Xu, Y.; Liu, J.-Q.*, The triterpenes and steroids from the fruiting body Ganoderma duripora. Biochemical Systematics and Ecology 2017, 73, 50-53.

6. Lian, C.-L.; Wu, Y.-Q.; Chen, T.-Q.; Liu, X.-Q.; Cong, H.; Xiao, L.; Xu, Y.; Liu, J.-Q.*, Identification of new trace triterpenoids from the fungus Ganoderma duripora. Phytochemistry Letters 2017, 21, 237-239.

7. Liu, J.-Q.; Yang, Y.-F.; J.-J; Li, X.-Y;Li,Z.-R; Zhou, L.;Qiu, M.-H*. Cytotoxic diterpenoids from Jatrophacurcas cv. Nigroviensrugosus CY Yang roots. Phytochemistry, 117, 462‒468, 2015.

8. Liu, J.-Q.; Deng, Y.-Y.1; Li, Y.; Li, T.-Z.; Han, Q.;Qiu, M.-H.*, Three New Tetranorditerpenes from Aerial Parts of Acerola Cherry (Malpighiaemarginata). Molecules, 19 (2), 2629-36, 2014.

9. Li X.-Y, Yang Y.-F, Peng X.-R, Li M.-M, Li L.-Q, Deng X, Qin H.-B*, Liu J.-Q*, Qiu M.-H*. One-Step Semisynthesis Method of Spirocurcasone and Pyracurcasone from Curcusones A and B. Organic Letters, 12(8),2196-2199, 2014.

10. Liu, J.-Q.; Yang, Y.-F.1; Li, X.-Y.; Liu, E.-Q.; Li, Z.-R.; Zhou, L.; Li, Y.; Qiu, M.-H.*,Cytotoxicity of naturally occurring rhamnofolane diterpenes from Jatropha curcas. Phytochemistry (Elsevier), 96, 265-272, 2013.

11. Liu, J.-Q.; Peng, X.-R.; Zhang, W.-M.; Shi, L.; Li, X.-Y.; Chen, J.-C.; Qiu, M.-H.*,Swietemahalactone, a rearranged phragmalin-type limonoid with anti-bacterial effect, fromSwietenia mahagoni. RSC Advances, 3, (15), 4890-4893, 2013.

12. Liu, J.-Q.; Peng, X.-R.; Li, X.-Y.; Li, T.-Z.; Zhang, W.-M.; Shi, L.; Han, J.; Qiu,M.-H.*,Norfriedelins A-C with acetylcholinesterase inhibitory activity from acerola tree(Malpighiaemarginata). Organic Letters, 15, (7), 1580-1583, 2013.

13. Liu, J.-Q.; Yang, Y.-F.; Wang, C.-F.; Li, Y.; Qiu, M.-H.*, Three new diterpenesfromJatrophacurcas. Tetrahedron, 68, (4), 972-976, 2012.

14. Liu, J.-Q.; Wang, C.-F.; Li, Y.; Luo, H.-R.; Qiu, M.-H.*, Isolation and bioactivityevaluation of terpenoids from the medicinal fungus Ganodermasinense. Planta Medica,78, (4), 368-376, 2012.

15. Liu, J.-Q.; Wang, C.-F.; Li, Y.; Chen, J.-C.; Zhou, L.; Qiu, M.-H.*, Limonoidsfromthe leaves of Toonaciliata var. yunnanensis. Phytochemistry (Elsevier), 76, 141-149, 2012.

16. Liu, J.-Q.; Wang, C.-F.; Chen, J.-C.; Qiu, M.-H.*, Limonoids from the leaves ofSwieteniamacrophylla. Natural Product Research, 26, (20), 1887-1891, 2012.

17. Liu, J.-Q.; Wang, C.-F.; Peng, X.-R.; Qiu, M.-H.*, New alkaloids from the fruitingbodies of Ganodermasinense. Natural Products and Bioprospecting, 1, (2), 93-96, 2011.

18. Liu, J.-Q.; Wang, C.-F.; Li, X.-Y.; Chen, J.-C.; Li, Y.; Qiu, M.-H.*, One newpregnane glycoside from the seeds of cultivated Bruceajavanica. Archives of PharmacalResearch, 34, (8), 1297-1300, 2011.

19. Liu, J.-Q.; Chen, J.-C.; Wang, C.-F.; Qiu, M.-H.*, One new cucurbitanetriterpenoid from the fruits of Momordicacharantia. European Journal of Chemistry, 1, (4), 294-296, 2010.

20. Liu, J.-Q.; Wang, C.-F.; Chen, J.-C.; Tu, S.-H.; Gu, H.-F.; Hu, W.-X.; Qiu, M.-H.*, Six New Triterpenoid Glycosides from Gynostemmapentaphyllum. Helvetica ChimicaActa 92, (12), 2737-2745, 2009.

21. Liu, J.-Q.; Chen, J.-C.; Wang, C.-F.; Qiu, M.-H., New cucurbitanetriterpenoids and steroidal glycoside from Momordicacharantia. Molecules 14, (12), 4804-4813, 2009.

22. Sun, A.-J.; Liu, J.-Q.; Pang, S.-Q.; Lin, J.; Xu, R.-A., Two novel phenanthraquinones with anti-cancer activity isolated from Bletilla striata. Bioorganic & Medicinal Chemistry Letters 2016,26 (9), 2375-2379.

23. Peng, X.-R.; Liu, J.-Q.; Wang, C.-F.; Li, X.-Y.; Shu, Y.; Zhou, L.; Qiu, M.-H.*, Hepatoprotective Effects of Triterpenoids from Ganoderma cochlear. Journal ofNatural Products,77(4), 737-743, 2014.

24. Peng, X.-R.; Liu, J.-Q.; Xia, J.-J.; Wang, C.-F.; Li, X.-Y.; Deng, Y.; Bao, N.-M.; Zhang, Z.-R.; Qiu, M.-H.*, Lanostanetriterpenoids from Ganodermahainanense J. D. Zhao. Phytochemistry,114, 137-245, 2014.

25. Peng, X..-R.; Liu, J.-Q.; Wang, C.-F.; Han, Z.-H.; Shu, Y.; Li, X.-Y.; Zhou, L.; Qiu, M.-H.*, Unusual prenylated phenols with antioxidant activities from Ganoderma cochlear. Food chemistry, 171, 251-257, 2015.

26. Zhao, G.-T.; Liu, J.-Q.; Deng, Y.-Y.; Li, H.-Z.; Chen, J.-C.; Zhang, Z.-R.; Zhou, L.; Qiu, M.-H.*, Cucurbitane-Type Triterpenoids from the Stems and Leaves of Momordicacharantia. Fitoterapia, 96, 79-82, 2014.

27. Shu, Y.; Liu, J.-Q.; Peng, X.-R.; Wan, L.-S.; Zhou, L.; Zhang, T.; Qiu, M.-H.*, Characterization of diterpenoidglucosides in roasted Puer coffee bean. Journal of Agricultural and Food Chemistry, 62 (12), 2631–2637, 2014.

28. Hu, K.; Liu, J.-Q.; Li, X.-N.; Chen, J.-C.; Zhang, W.-M.; Li, Y.; Li, L.-Q.; Guo,L.-L.; Ma, W.-G.; Qiu, M.-H.*, Chukfuransins A-D, Four new phragmalinlimonoids with-furan ring involved in skeleton reconstruction from Chukrasiatabularis. OrganicLetters, 15, (15), 3902-3905, 2013.

29. Peng, X.-R.; Liu, J.-Q.; Han, Z.-H.; Yuan, X.-X.; Luo, H.-R.; Qiu, M.-H.*,Protective effects of triterpenoids from Ganodermaresinaceum on H2O2-induced toxicity inHepG2 cells. Food Chemistry, 141, (2), 920-926, 2013.

30. Wang, H.-W.; Liu, J.-Q.; Chen, J.-X.; Yang, Y.-F.; Yan, Y.-X.; Li, Z.-R.; Qiu,M.-H.*, New triterpenoids from the kernels of Azadirachtaindica. Natural Products andBioprospecting, 3, (1), 33-37, 2013.

31. Yang, Y. F.; Liu, J. Q.; Li, X. Y.; Liu, E. Q.; Li, Z. R.; Qiu, M. H.*, New terpenoidsfrom the roots of Jatrophacurcas. Chinese Science Bulletin, 58, (10), 1115-1119, 2013.

32. Yang, Y.-F.; Liu, J.-Q.; Li, Z.-R.; Li, Y.; Qiu, M.-H.*, New eudesmenoicacidmethyl esters from the seed oil of Jatrophacurcas. Fitoterapia, 89, 278-284, 2013.

33. Yang, Y.-F.; Liu, J.-Q.; Shi, L.; Li, Z.-R.; Qiu, M.-H.*, New jatropholane-typediterpenesfromJatrophacurcas cv. Multiflorum CY Yang. Natural Products andBioprospecting, 3, (3), 99-102, 2013.

34. Peng, X. R.; Liu, J. Q.; Wan, L. S.; Li, X. N.; Yan, Y. X.; Qiu, M. H.*, Four new polycyclic meroterpenoids from Ganoderma cochlear. Organic letters, 16, (20), 5262-5265, 2014.

35. Yan, Yu-Xin; Liu, Jie-Qing; Wang, Hong-Wei; Chen, Jin-Xiong; Chen, Jian-Chao; Chen, Li; Zhou, Lin; Qiu, Ming-Hua; Identification and Antifeedant Activities of Limonoids from Azadirachtaindica; Chemistry & Biodiversity (2015), 12(7), 1040-1046.

36. Peng, XingRong; Liu, JieQing; Wang, CuiFang; Han, ZhongHui; Shu, Yi; Li, XuYang; Zhou, Lin; Qiu, MingHua; Unusual prenylated phenols with antioxidant activities from Ganoderma cochlear; Food Chemistry (2015), 171, 251-257.

37. Yan, Yu-Xin; Liu, Jie-Qing; Chen, Jin-Xiong; Chen, Jian-Chao; Qiu, Ming-Hua; Three new limonoids from Azadirachtaindica; Journal of Asian Natural Products Research (2015), 17(1), 14-19.

38. Chen Jian-Chao; Liu Jie-Qing; Zhou Lin; Qiu Ming-Hua; Lau Clara Bik-San; Chan Judy Yuet-Wa; Fung Kwok-Pui; Leung Ping-Chung; Xie Ming-Jin; The antigluconeogenic activity of cucurbitacins from Momordicacharantia; Plantamedica (2015), 81(4), 327-332.

39. Jiang, S.-Y.; Liu, J.-Q.; Xia, J.-J.; Yan, Y.-X.; Qiu, M.-H.*, Five newtetranortriterpenoids from the seeds of Toonaciliata. Helvetica ChimicaActa, 95, (2),301-307, 2012.

40. Peng, X.-R.; Liu, J.-Q.; Xia, J.-J.; Yang, Y.-H.; Qiu, M.-H.*, Two new triterpenoidsfromGanoderma cochlear. Zhongcaoyao, 43, (6), 1045-1049, 2012.

41. Wang, C.-F.; Liu, J.-Q.; Yan, Y.-X.; Chen, J.-C.; Lu, Y.; Guo, Y.-H.; Qiu, M.-H.*, Three new triterpenoidscontaining four-membered ring from the fruiting body of Ganodermasinense. Organic Letters, 12, (8), 1656-1659, 2010.

42. Cheng, B.-H.; Chen, J.-C.; Liu, J.-Q.; Zhou, L.; Qiu, M.-H.*, Cucurbitane-typetriterpenoids from Momordicacharantia. Helvetica ChimicaActa, 96, (6), 1111-1120, 2013.

43. Xu, W.-X.; Chen, J.-C.; Liu, J.-Q.; Zhou, L.; Wang, Y.-F.; Qiu, M.-H.*, Three newphysalins from Physalisalkekengi var. franchetii. Natural Products and Bioprospecting,3, (3), 103-106, 2013.

44. 徐颖,肖磊,连晨蕾,肖琴,刘接卿*.内生真菌抗肿瘤活性成分的研究进展[J].海峡药学,2018,30(07):1-7.

45. 连晨蕾,丛慧,吴雅清,刘绪强,刘接卿*.抗过敏天然产物研究进展[J].中国药学杂志,2017,52(12):997-1004.

46. 吴雅清,姜宏瑛,刘接卿,马国兴,刘嘉,许瑞安.星虫动物的化学成分及药理作用研究进展[J].中国海洋药物,2015,34(05):86-92.

47. 邱明华,张枝润,李忠荣,周琳,储瑞,刘接卿,王卫华.咖啡化学成分与健康[J].植物科学学报,2014,32(05):540-550.

48. 邓媛元,张名位,刘接卿,张雁,张瑞芬,魏振承,遆慧慧,刘磊,邱明华.不同品种苦瓜多糖含量及其抗氧化和α-葡萄糖苷酶抑制活性比较[J].现代食品科技,2014,30(09):102-108.

49. 彭惺蓉,刘接卿,夏建军,杨永红,邱明华.反柄紫芝中2个新三萜类化合物[J].中草药,2012,43(06):1045-1049.

50. 刘接卿,王翠芳,邱明华,胡文祥.玉簪花的抗肿瘤活性甾体皂苷成分研究[J].中草药,2010,41(04):520-526.

51. 胡文祥. 微波催化在有机药物化学中的应用研究[A]. 中国化学会.中国化学会第26届学术年会应用化学分会场论文集[C].中国化学会:中国化学会,2008:1.

52. 刘接卿. 绞股蓝总皂苷微波萃取及其纯化工艺的研究[A]. 中国化学会.中国化学会第26届学术年会有机化学分会场论文集[C].中国化学会:中国化学会,2008:1.