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蔡双凤讲师

发布时间:2020-02-24 浏览次数:

 

基本信息:

蔡双凤讲师

硕士生导师(可招收学硕与专硕研究生)

邮箱:caisf@hqu.edu.cn

 

教育经历:

2007/09-2015/01,中国科学院,微生物研究所,遗传学专业,博士,

2003/09-2007/07,北京大学,生命科学学院,生物科学专业,学士

科研与学术工作经历:

2015/03-至今,华侨大学,生物医学学院,讲师。

研究方向:

生物医学材料开发与应用,海洋生物活性蛋白研究

主持或参加科研项目(课题)及人才计划项目情况:

1. 国家自然科学基金青年项目,31700071,基于嗜盐古菌phaP/phaR重组表达的PHA颗粒粒径控制研究,2018/01-2020/1222万元,在研,主持

2. 福建省青年科技人才创新项目2017J05052海洋星虫纤溶酶的表达体系及溶栓机制研究2017/4-2020/4,4万元,在研,主持

3. 泉州市社发领域科技创新项目,2019N113S,基于全新生理靶点人工甜味剂干扰机体葡萄糖耐受的风险研究,2019/12-2022/12,20万,在研,主持

4. 华侨大学科研启动费项目-引进人才类(NO. 15BS414),海洋星虫纤溶酶的表达水平检测及其高效表达系统的建立,2015/11-2018/11,4万元,在研,主持

5. 福建省海洋经济创新发展区域示范项目,2014FJPT08,台湾海峡海洋抗血栓纤溶酶基因库,2014/01-2016/12,1350万,在研,参加。

6. 国家自然科学基金重点项目,31330001,极端嗜盐古菌固碳贮碳及其代谢新途径研究,2014/01-2018/12,302万元,结题,参加。

代表性研究成果:

第一或通讯作者:

 (1) Cai, Shuangfeng(#)Cai, LeiLiu, HailongLiu, XiaoqingHan, JingZhou, JianXiang, HuaIdentification of the haloarchaeal phasin (PhaP) that functions in polyhydroxyalkanoate accumulation and granule formation in Haloferax mediterranei.Appl Environ Microbiol2012.3.01786):1946~1952 (被引>60次)

(2) Cai, Shuangfeng(#)Cai, LeiZhao, DaheLiu, GuimingHan, JingZhou, JianXiang, Hua(*)A novel DNA-binding protein, PhaR, plays a central role in the regulation of polyhydroxyalkanoate accumulation and granule formation in the haloarchaeon Haloferax mediterranei.Appl Environ Microbiol2015.1.01811):373~385

(3) 高三星(#),蔡双凤(*),许瑞安腺相关病毒介导的肝细胞癌靶向治疗策略药学学报2017.529):1359-1365

主要参与完成:

(1) Liu, Guiming(#)Cai, ShuangfengHou, JingZhao, DaheHan, JingZhou, JianXiang, HuaEnoyl-CoA hydratase mediates polyhydroxyalkanoate mobilization in Haloferax mediterranei.Sci Rep2016.4.7624015~24015

(2) Cai, Lei(#)Cai, ShuangfengZhao, DaheWu, JinhuaWang, LeiLiu, XiaoqingLi, MingHou, JingZhou, JianLiu, JingfangHan, JingXiang, HuaAnalysis of the transcriptional regulator GlpR, promoter elements, and posttranscriptional processing involved in fructose-induced activation of the phosphoenolpyruvate-dependent sugar phosphotransferase system in Haloferax mediterranei.Appl Environ Microbiol2014.2.01804):1430~1440

(3) Yang, Haibo(#)Wu, ZhenfangLiu, JingfangLiu, XiaoqingWang, LeiCai, ShuangfengXiang, HuaActivation of a dormant replication origin is essential for Haloferax mediterranei lacking the primary origins.Nat Commun2015.01.0168321~8321

(4) Liu, Guiming(#)Hou, JingCai, ShuangfengZhao, DaheCai, LeiHan, JingZhou, JianXiang, Hua(*)A patatin-like protein associated with the polyhydroxyalkanoate (PHA) granules of Haloferax mediterranei acts as an efficient depolymerase in the degradation of native PHA.Appl Environ Microbiol2015.5.1819):3029~3038

(5) Wul, Jinhua(#)Cai, ShuangfengLiu, HailongHou, JingHan, JingZhou, JianHua, Xiang[Development of PhaP-tagged protein expression and purification systems for extremely halophilic archaea ].Acta Microbiologica Sinica2014.9.4549):998~1009

(6) Cai, Lei(#)Zhao, DaHeHou, JingWu, JinHuaCai, ShuangFengDassarma, PriyaXiang, HuaCellular and organellar membrane-associated proteins in haloarchaea: perspectives on the physiological significance and biotechnological applications.Sci China Life Sci2012.5.01555):404~414

(7) Liu, Hailong(#)Luo, YuanmingHan, JingWu, JinhuaWu, ZhenfangFeng, DeqinCai, ShuangfengLi, MingLiu, JingfangZhou, JianXiang, HuaProteome reference map of Haloarcula hispanica and comparative proteomic and transcriptomic analysis of polyhydroxyalkanoate biosynthesis under genetic and environmental perturbations.J Proteome Res2013.3.1123):1300~1315

(8) Han, Jing(#)Hou, JingZhang, FanAi, GuominLi, MingCai, ShuangfengLiu, HailongWang, LeiWang, ZejianZhang, SiliangCai, LeiZhao, DaheZhou, JianXiang, HuaMultiple propionyl coenzyme A-supplying pathways for production of the bioplastic poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in Haloferax mediterranei.Appl Environ Microbiol2013.5.01799):2922~2931