吴四海

-个人简介

副教授

硕士生导师

福建省高层次人才C类(2023年度

泉州市高层次人才第三层次(2023年度

华侨大学医学院实验教学中心副主任/工会副主席/党支部书记

-教育工作经历

2016.01-至今         华侨大学医学院

2013.11- 2014.03   法国雷恩第一大学 学术交流 访问学者

2010.09- 2015.06   中国科学院化学所 有机化学(硕博连读 博士学位

2006.09- 2010.06   湘潭大学 应用化学 学士学位


-主讲课程

1. 无机化学 

2. 医用化学



-研究兴趣

1. 双重发射金属配合物的合成与生物大分子(DNA和蛋白检测 

2. 发光功能配合物的设计与OLED应用


-科研项目

1. 国家自然科学青年基金,22004041,基于双重发射金属钌配合物的蛋白纤维化检测,2021/01 - 2023/12,24万元,在研,主持

2. 泉州市科技计划项目,2019C064R,金属配合物蓝光材料的设计合成及其在有机发光二极管中的应用,2019/09 - 2022/08,30万元,结题,主持

3. 华侨大学科研启动基金,600005-Z16X0045,基于二茂铁多中心混合价体系的研究,2016/05 - 2019/05,4万元,结题,主持

4. 国家自然科学青年基金,81602970,新型小分子procaspase3变构激活剂的分子构建和抗肿瘤活性评价,2016/10 - 2019/10,17.3万元,结题,参与


-代表性论文(通讯或第一作者)

12. Si-Hai Wu*, Zhe Zhang, Ren-Hui Zheng, Rong Yang, Lianhui Wang*, Jiang-Yang Shao, Zhong-Liang Gong* and Yu-Wu Zhong. Dual-Emissive Monoruthenium Complexes of N(CH3)-Bridged Ligand: Synthesis, Characterization, and Substituent Effect. Materials 2023, Accepted. (Invited Paper, SCI三区)

11. Hailong Wang, Haichao Huang, Chao Gong, Yong Diao, Jianmei Chen, Si-Hai Wu*, and Lianhui Wang*. Nickel-Catalyzed Chemo- and Regioselective Benzylarylation of Unactivated Alkenes with o-Bromobenzyl Chlorides. Org. Lett. 2022, 24, DOI: 10.1021/acs.orglett.1c03991. (SCI二区)

10. Haichao Huang, Hailong Wang, Chao Gong, Zhenjing Zhuang, Wenmin Feng, Si-Hai Wu* and Lianhui Wang*. Synthesis of 2-trifluoromethylquinolines through rhodiumcatalysed redox-neutral [3+3] annulation between anilines and CF3-ynones using traceless directing group. Org. Chem. Front. 2022, 9, DOI:10.1039/D1QO01478A. (SCI二区)

9. Yu Wang, Kun Huang, Yali Gao, Dandan Yuan, Lin Ling, Jieqing Liu, Si-Hai Wu, Roufen Chen, He Li, Yizu Xiong, Han Liu, Junjie Ma*. Discovery of quinazoline derivatives as novel small-molecule inhibitors targeting the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) interaction. Eur. J. Med. Chem. 2022, 229, DOI:10.1016/j.ejmech.2021.113998. (SCI二区)

8. Si-Hai Wu*, Rong Yang, Bin Sun, Jian-Hong Tang, Zhong-Liang Gong, Junjie Ma, Lianhui Wang, Jieqing Liu, Dian-Xue Ma, Jiang-Yang Shao*, Yu-Wu Zhong*. Dual-Emissive Tris-Heteroleptic Ruthenium Complexes: Tuning the DNA-Triggered Ratiometric Emission Response by Ancillary Ligands. Inorg. Chem. 2021, 60,14810–14819. (SCI二区, Top期刊)

7. Si-Hai Wu*, Dian-Xue Ma, Zhong-Liang Gong, Junjie Ma, Rong Yang, Jiang-Yang Shao*, Yu-Wu Zhong*. Synthesis, Photophysical, and Computational Studies of a Bridged IrIII-PtII Heterodimetallic Complex. Crystals 2021, 11, 236. (Invited Paper, SCI三区)

6. Si-Hai Wu*, Jiang-Yang Shao, Zifeng Zhao, Junjie Ma, Rong Yang, Na Chen, Jian-Hong Tang*, Zuqiang Bian, Yu-Wu Zhong*. Ligand Engineering toward Deep Blue Emission in Nonplanar Terdentate Platinum(II) Complexes. Organometallics 2021, 40, 156–165. (SCI二区)

5. Jiang-Yang Shao, Si-Hai Wu*, Junjie Ma, Zhong-Liang Gong, Tian-Ge Sun, Yulong Jin, Rong Yang, Bin Sun, Yu-Wu Zhong*. Ratiometric detection of amyloid-b aggregation by a dual-emissive tris-heteroleptic ruthenium complex. Chem. Commun. 2020, 56, 2087–2090. (Front Cover, SCI二区)

4. Si-Hai Wu*, Zhong-Liang Gong, Jiang-Yang Shao, Rong Yang, Yu-Wu Zhong*. Dual-emissive transition-metal complexes and their applications as ratiometric photoluminescent probes. Sci. Sin. Chim. 2020, 50, 315–323. (Invited Review, 特刊)

3. Zhi-Juan Li, Jiang-Yang Shao, Si-Hai Wu*, Yu-Wu Zhong*. Nanocrystalline Sb-doped SnO2 films modified with cyclometalated ruthenium complexes for two-step electrochromism. Dalton Trans. 2019, 48, 2197–2205. (SCI二区)

2. Si-Hai Wu*, Jiang-Yang Shao, Zhong-Liang Gong, Na Chen, Yu-Wu Zhong*. Tuning the dual emissions of a monoruthenium complex with a dangling coordination site by solvents, O2, and metal ions. Dalton Trans. 2018, 47, 292–297. (SCI二区)

1. Si-Hai Wu*, Jiang-Yang Shao, Xiaojuan Dai, Xiuling Cui, Yu-Wu Zhong*. Synthesis and Characterization of Trisbidentate Ruthenium Complexes of Di(pyrid-2-yl)-methylamine. Eur. J. Inorg. Chem. 2017, 2017, 3064–3071. (SCI三区)

2016年以前:

1. Yu-Wu Zhong*, Si-Hai Wu, Stephen E. Burkhardt, Chang-Jiang Yao, Héctor D. Abruña*. Mononuclear and Dinuclear Ruthenium Complexes of 2,3-Di-2-pyridyl-5,6-diphenylpyrazine: Synthesis and Spectroscopic and Electrochemical Studies. Inorg. Chem. 2011, 50, 517–524. (SCI二区)

2. Si-Hai Wu, Stephen E. Burkhardt, Jiannian Yao, Yu-Wu Zhong*, Héctor D. Abruña*. Near-Infrared Absorbing and Emitting RuII−PtII Heterodimetallic Complexes of Dpdpz (Dpdpz = 2,3-Di(2-pyridyl)-5,6-diphenylpyrazine). Inorg. Chem. 2011, 50, 3959–3969. (SCI二区)

3. Si-Hai Wu, Héctor D. Abruña, and Yu-Wu Zhong*. Rhenium Complexes of 2,3-Di(2-pyridyl)-5,6-diphenylpyrazine: Synthesis, Characterization, and Reactivity. Organometallics 2012, 31, 1161–1167. (SCI二区)

4. Si-Hai Wu, Stephen E. Burkhardt, Yu-Wu Zhong*, Héctor D. Abruña*. Cyclometalated Ruthenium Oligomers with 2,3-Di(2-pyridyl)-5,6-diphenylpyrazine: A Combined Experimental, Computational, and Comparison Study with Noncyclometalated Analogous. Inorg. Chem. 2012, 51, 13312–13320. (SCI二区)

5. Si-Hai Wu, Jun-Jian Shen, Jiannian Yao, Yu-Wu Zhong*. Asymmetric Mixed-Valence Complexes that Consist of Cyclometalated Ruthenium and Ferrocene: Synthesis, Characterization, and Electronic Coupling Studies. Chem. Asian J. 2013, 8, 138-147. (SCI二区)

6. You-Ming Zhang#, Si-Hai Wu#, Chang-Jiang Yao , Hai-Jing Nie , Yu-Wu Zhong*. A Bis(terpyridine)ruthenium Complex with Three Redox-Active Amine Sites: Electrochemical, Optical, and Computational Studies. Inorg. Chem. 2012, 51, 11387–11395. (SCI二区, 共同一作)

7. Si-Hai Wu, Yu-Wu Zhong*, Jiannian Yao. 2,3-Di(2-pyridyl)-5-phenylpyrazine: A NN-CNN-Type Bridging Ligand for Dinuclear Transition-Metal Complexes. Chem. Asian J. 2013, 8, 1504-1513. (SCI二区)

8. Si-Hai Wu, Jiang-Yang Shao, Hong-Wei Kang, Jiannian Yao, Yu-Wu Zhong*. Substituent and Solvent Effects on the Electrochemical Properties and Intervalence Transfer in Asymmetric Mixed-Valent Complexes Consisting of Cyclometalated Ruthenium and Ferrocene. Chem. Asian J. 2013, 8, 2843-2850. (SCI二区)

-授权发明专利

1. 吴四海、刘接卿、马俊杰,一种有机蓝色发光材料及其制备方法,2020-08-07,中国,ZL201711093178.5

2. 吴四海,一种金属钌配合物比率发光探针及其制备和利用该发光探针检测淀粉样蛋白纤维化过程的应用,2022-10-14,中国,ZL201911068985.0

3. 吴四海,一种铂配合物蓝光材料及其制备和应用,2023-07-18,中国,ZL202011110875.9


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