一、基本情况
姓名：蔡文杰
性别：男
出生年月：1975年10月
邮箱：caiwj2001@126.com
单位：泉州市第一医院
专业职称：主任医师
职务：放疗科副主任，MDT中心主任，伦理委员会副主任
二、教育经历（起止时间、学校、专业）
2003/10 - 2008/7，福建医科大学，肿瘤学，硕士
1993/9 - 1998/8，福建医科大学，临床医学，学士
三、主要工作经历（起止时间、地点、工作单位部门、任职）
2021/11至今，泉州市第一医院，主任医师
2014/09至2021/11，泉州市第一医院，副主任医师
2008/01– 2014/09，泉州市第一医院，主治医师
1998/08– 2008/01，泉州市第一医院，住院医师
四、研究方向
恶性肿瘤放疗及系统治疗
五、近五年其他突出业绩（研究成果、研究项目、发明专利、突出贡献、突出业绩等）
1) Nan Miao1 ,Xiaodong Lai, Zhiwei Zeng,Wenjie Cai,Wanhua Chen,Tao Sun, Differential expression of microRNAs in the human fetal left and right cerebral cortex. Mol Biol Rep. 2020 Sep;47(9):6573-6586.
2) SHUNZHONG HONG, WENJIE CAI, ZICHENG HUANG, YUBIN WANG, XIFENG MI, YISEN HUANG, ZHIJIN LIN and XIANGBO CHEN, Ginsenoside Rg3 enhances the anticancer effect of 5 FU in colon cancer cells via the PI3K/AKTpathway. ONCOLOGY REPORTS 44: 1333-1342, 2020
3) Yuan Yu , Zhiwei Zeng, Danlin Xie, Renliang Chen, Yongqiang Sha, Shiying Huang, Wenjie Cai, Wanhua Chen, Wenjun Li, Rongqin Ke and Tao Sun, Interneuron origin and molecular diversity in the human fetal brain.Nat Neurosci 2021 Nov 4.
4) Yongqiang Sha, Wenjie Cai, Alani mohanad Khalid, Qingjia Chi, Jing Wang, Tao Sun, Chunli Wang, Pretreatment with mechano growth factor E peptide attenuates osteoarthritis through improving cell proliferation and extracellular matrix synthesis in chondrocytes under severe hypoxia. International Immunopharmacology,2021 Aug;97:107628
5）Zhenyu Lin, Wenjie Cai(共同第一作者), Wentai Hou, Yayuan Chen, Bingzong Gao, Runzhi Mao, Liansheng Wang*, Member, IEEE, and Zirong Li*，CT-Guided Survival Prediction of Esophageal Cancer，IEEE Journal of Biomedical and Health Informatics，2022 Jun;26(6):2660-2669.
6）Nan Miao, Wenjie Cai(共同第一作者), Sijia Ding,Yajuan Liu,Wanhua Chen Tao Sun,Characterization of plasma exosomal microRNAs in responding to radiotherapy of human esophageal squamous cell carcinoma, Molecular Medicine report 26: 287, 2022
7）Cai W, Hong IW, Cai C, Chen W. Unveiling Survival Predictors in Postoperative Head and Neck Cancer: A Comprehensive Analysis. Japan J Res. 2025;6(7):129
8）Wenjie Cai,Yayun Chen, Kaixin Li, Bingzhong Gao, Runzhi Mao and Wanhua Chen*. Sintilimab as an Effective Treatment for Recurrent Cutaneous Squamous Cell Carcinoma in an Elderly Patient Post Radiotherapy: A Case Report. COJ Nurse Healthcare. 9(3). COJNH. 000712. 2025.
9）Guo X, Lee T, Sun J, Sun J, Cai W, Yang Q, Sun T.Molecular Lineages and Spatial Distributions of Subplate Neurons in the Human Fetal Cerebral Cortex.Adv Sci (Weinh). 2024 Dec;11(47):e2407137.
10）Zheng C, Tu C, Wang J, Yu Y, Guo X, Sun J, Sun J, Cai W, Yang Q, Sun T.Deciphering Oligodendrocyte Lineages in the Human Fetal Central Nervous System Using Single-Cell RNA Sequencing.Mol Neurobiol. 2024 Mar;61(3):1737-1752.
11）Miao N, Zeng Z, Lee T, Guo Q, Zheng W, Cai W, Chen W, Wang J, Sun T.Integrative epigenome profiling of 47XXY provides insights into whole genomic DNA hypermethylation and active chromatin accessibility.Front Mol Biosci. 2023 Mar 27;10:1128739.
12）Wang J, Chen Z, He F, Lee T, Cai W, Chen W, Miao N, Zeng Z, Hussain G, Yang Q, Guo Q, Sun T.Single-Cell Transcriptomics of Cultured Amniotic Fluid Cells Reveals Complex Gene Expression Alterations in Human Fetuses With Trisomy 18.Front Cell Dev Biol. 2022 Mar 22;10:825345. doi: 10.3389/fcell.2022.825345. eCollection 2022.
13）Yu Y, Zeng Z, Xie D, Chen R, Sha Y, Huang S, Cai W, Chen W, Li W, Ke R, Sun T.Interneuron origin and molecular diversity in the human fetal brain.Nat Neurosci. 2021 Dec;24(12):1745-1756.
14）获2019年福建省科技进步奖一等奖（基于放疗的食管癌个体化精准治疗的临床研究，第三完成人）
15）专利一项：经皮肿物穿刺针固定器（专利号:ZL202120359714.7）
六、近五年指导专业学位研究生情况（指导学位论文，参与学位论文开题、中期、预答辩、答辩等）
指导专业硕士7人
